Naloxone Market: How Is the Shift to Fentanyl-Dominated Drug Supply Affecting Naloxone Product Development?
Fentanyl's pharmacological challenge to standard naloxone dosing — the illicit drug supply's near-complete contamination with fentanyl and its potent analogs (carfentanil, acetyl fentanyl, nitazenes increasingly) — creating a pharmacological environment where standard naloxone doses (0.4-2mg) may be insufficient for complete reversal or require multiple sequential doses —...
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